{"id":3552,"date":"2023-07-25T07:43:56","date_gmt":"2023-07-25T13:43:56","guid":{"rendered":"https:\/\/udibi6748.live-website.com\/?page_id=3552"},"modified":"2023-07-25T07:45:08","modified_gmt":"2023-07-25T13:45:08","slug":"immunomodulator-udiz-002","status":"publish","type":"page","link":"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/","title":{"rendered":"Immunomodulator UDIZ-002"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<h3><strong>Immunomodulator UDIZ-002<\/strong><\/h3>\n<p>Within our portfolio, we have the UDIZ-002 project, whose objective is the development of a ubiquitin-based immunomodulator. Monomeric ubiquitin is the main component of Transferon Oral\u00ae.<\/p>\n<p><strong>Proposed mechanism of action<\/strong><\/p>\n<p>Intravenously administered ubiquitin reduces inflammation and increases the survival rate in preclinical models of sepsis. It acts extracellularly as a cytokine-like protein with anti-inflammatory properties, probably through interaction with the CXCR-4\/CXCL12 axis or through cellular internalization by mechanisms still under investigation.<\/p>\n<p><strong>Objective of the project<\/strong><\/p>\n<p>Develop a small protein with modulatory effects on the immune system for oral administration, capable of controlling inflammation in diseases such as allergic rhinitis.<\/p>\n<p><strong>Reference<\/strong><\/p>\n<p>Majetschak M. Extracellular ubiquitin: immune modulator and endogenous opponent of damage-associated molecular pattern molecules.\u00a0J. Leukoc. Biol. 2011;\u00a0 89(2). Doi: 10.1189\/jlb.0510316<\/p>\n<p>&nbsp;<\/p>\n<p>Vallejo-Castillo L, et al. Sequencing Analysis and Identification of the Primary Peptide Component of the Dialyzable Leukocyte Extract \u00abTransferon Oral\u00bb: The Starting Point to Understand Its Mechanism of Action. Front Pharmacol. 2020; 11:569039. doi: 10.3389\/fphar.2020.569039.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] Immunomodulator UDIZ-002 Within our portfolio, we have the UDIZ-002 project, whose objective is the development of a ubiquitin-based immunomodulator. Monomeric ubiquitin is the main component of Transferon Oral\u00ae. Proposed mechanism of action Intravenously administered ubiquitin reduces inflammation and increases the survival rate in preclinical models of sepsis. It acts extracellularly as a cytokine-like protein with anti-inflammatory properties, probably through [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"pmpro_default_level":"","footnotes":""},"class_list":["post-3552","page","type-page","status-publish","hentry","pmpro-has-access"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Immunomodulator UDIZ-002 - UDIBI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immunomodulator UDIZ-002 - UDIBI\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text] Immunomodulator UDIZ-002 Within our portfolio, we have the UDIZ-002 project, whose objective is the development of a ubiquitin-based immunomodulator. Monomeric ubiquitin is the main component of Transferon Oral\u00ae. Proposed mechanism of action Intravenously administered ubiquitin reduces inflammation and increases the survival rate in preclinical models of sepsis. It acts extracellularly as a cytokine-like protein with anti-inflammatory properties, probably through [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/\" \/>\n<meta property=\"og:site_name\" content=\"UDIBI\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-25T13:45:08+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/\",\"url\":\"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/\",\"name\":\"Immunomodulator UDIZ-002 - UDIBI\",\"isPartOf\":{\"@id\":\"https:\/\/udibi.com.mx\/en\/#website\"},\"datePublished\":\"2023-07-25T13:43:56+00:00\",\"dateModified\":\"2023-07-25T13:45:08+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\/\/udibi.com.mx\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Immunomodulator UDIZ-002\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/udibi.com.mx\/en\/#website\",\"url\":\"https:\/\/udibi.com.mx\/en\/\",\"name\":\"UDIBI\",\"description\":\"IPN\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/udibi.com.mx\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Immunomodulator UDIZ-002 - UDIBI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/","og_locale":"en_US","og_type":"article","og_title":"Immunomodulator UDIZ-002 - UDIBI","og_description":"[vc_row][vc_column][vc_column_text] Immunomodulator UDIZ-002 Within our portfolio, we have the UDIZ-002 project, whose objective is the development of a ubiquitin-based immunomodulator. Monomeric ubiquitin is the main component of Transferon Oral\u00ae. Proposed mechanism of action Intravenously administered ubiquitin reduces inflammation and increases the survival rate in preclinical models of sepsis. It acts extracellularly as a cytokine-like protein with anti-inflammatory properties, probably through [&hellip;]","og_url":"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/","og_site_name":"UDIBI","article_modified_time":"2023-07-25T13:45:08+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/","url":"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/","name":"Immunomodulator UDIZ-002 - UDIBI","isPartOf":{"@id":"https:\/\/udibi.com.mx\/en\/#website"},"datePublished":"2023-07-25T13:43:56+00:00","dateModified":"2023-07-25T13:45:08+00:00","breadcrumb":{"@id":"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/udibi.com.mx\/en\/immunomodulator-udiz-002\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/udibi.com.mx\/en\/"},{"@type":"ListItem","position":2,"name":"Immunomodulator UDIZ-002"}]},{"@type":"WebSite","@id":"https:\/\/udibi.com.mx\/en\/#website","url":"https:\/\/udibi.com.mx\/en\/","name":"UDIBI","description":"IPN","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/udibi.com.mx\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/udibi.com.mx\/en\/wp-json\/wp\/v2\/pages\/3552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/udibi.com.mx\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/udibi.com.mx\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/udibi.com.mx\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/udibi.com.mx\/en\/wp-json\/wp\/v2\/comments?post=3552"}],"version-history":[{"count":2,"href":"https:\/\/udibi.com.mx\/en\/wp-json\/wp\/v2\/pages\/3552\/revisions"}],"predecessor-version":[{"id":3554,"href":"https:\/\/udibi.com.mx\/en\/wp-json\/wp\/v2\/pages\/3552\/revisions\/3554"}],"wp:attachment":[{"href":"https:\/\/udibi.com.mx\/en\/wp-json\/wp\/v2\/media?parent=3552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}